Although uterus transplants are a growing area of medicine, they remain experimental and are very difficult surgeries to complete.
A mother has given birth to a healthy baby girl after surgeons implanted a womb in her body from a deceased donor.
The case study – published in The Lancet – in Brazil demonstrates that uterus donations from deceased donors are a potential avenue of treatment for women with uterine infertility.
Although uterus transplants are a growing area of medicine, they remain highly experimental and are very difficult surgeries to complete.
Uterine transplants from living donors have occurred before. A total of 39 transplants have resulted in 11 live births – with the first taking place in Sweden in 2013.
There have been 10 uterus transplants from deceased donors attempted in the US, the Czech Republic, and Turkey, but this is the first one which resulted in a live birth.
The surgery described in the case study took place in September 2016, and notes that a 32-year-old woman who had been born without a uterus was the recipient of the transplant.
This woman had a single in-vitro fertilisation (IVF) cycle four months before the transplant took place, which resulted in eight fertilised eggs which were cryopreserved.
The donor was a 45-year-old woman who died of subarachnoid haemorrhage – a type of stroke involving bleeding on the surface of the brain.
In a surgery lasting 10 and a half hours, the uterus was removed from the donor and transplanted into the recipient, where it was connected to the recipient’s veins and arteries as well as her ligaments and vaginal canals.
She stayed in intensive care for two days after the surgery and then spent six more on a specialised transplant ward.
The woman received five immunosuppression drugs, as well as antimicrobials, anti-blood clotting treatment and aspirin while in hospital, and immunosuppression was continued up until the woman gave birth.
Five months after the transplant, the uterus showed no signs of rejection and the recipient was menstruating regularly.
Her fertilised eggs were implanted after seven months – and 10 days after implantation, the recipient was confirmed to be pregnant.